Science

Harnessing the synergy of nature for targeted inflammatory relief

Overview

Phyto-N is a botanical drug candidate derived from a medicinal plant with a history of human use. It is an extract from a single plant species, containing multiple chemical components. Research over the past 30 years has focused on understanding its chemical composition and pharmacological activities. Preclinical studies suggest Phyto-N may have anti-inflammatory effects, potentially acting on multiple targets related to immune-inflammatory diseases. Clinical trials are needed to evaluate its efficacy and safety in humans.

Traditional Use in China

Phyto-N, derived from a plant used in traditional Chinese medicine, has been administered by practitioners to patients with inflammatory conditions over the past 30 years in China. Observational reports suggest outcomes in some patients, including those with ulcerative colitis. These reports from traditional use have informed further research into Phyto-N's potential therapeutic applications.

Preclinical Evaluation

Preclinical studies on Phyto-N have been conducted in animal models of six inflammatory diseases at various research institutes, including Rutgers University. These preliminary results have suggested potential effects on inflammatory conditions. Safety studies in experimental animals at tested doses have not shown observable toxicity. These findings have encouraged continued investigation into Phyto-N's properties.

Compound Identification

The research team is currently working to identify and isolate specific chemical compounds in Phyto-N. This process involves the use of various analytical techniques to understand the extract's composition. The goal is to potentially develop these compounds into small molecule drugs. This ongoing research aims to explore new therapeutic possibilities based on Phyto-N's components.

Advantages

History of use in Chinese Traditional Medicine

Phyto-N’s history of human use in Chinese traditional medicine may provide an encouraging insight for multiple inflammatory diseases that may inform our clinical development process, though further rigorous studies are needed.

Broad therapeutic potential

Phyto-N has shown effects in animal models across several inflammatory diseases, highlighting its versatility and potential to treat multiple indications with a single drug.

Potential multi-target mechanism of action

Phyto-N may modulate multiple inflammatory pathways simultaneously, potentially providing a more comprehensive treatment effect compared to single-target agents, with the potential to address complex disease pathologies and overcome treatment resistance.

Potential for tolerability

Phyto-N’s botanical origin and potential multi-target mechanism may contribute to a favorable tolerability profile, and comprehensive clinical trials are needed to establish Phyto-N’s safety profile as a pharmaceutical product.

Development

These promising results of Phyto-N, as demonstrated in animal disease models and its use in traditional Chinese medicine, have motivated us to undertake rigorous scientific research and clinical development to further evaluate its therapeutic potential. We are currently preparing for an IND application and planning clinical trials for Phyto-N. If these efforts are successful and lead to regulatory approval, we believe that Phyto-N will address diverse medical needs. However, Phyto-N has not received regulatory approval as a drug in any jurisdiction, including China, and drug development is a complex, lengthy, and uncertain process, and there can be no assurance of clinical or commercial success.